• C-reactive protein levels and depression in older and younger adults - A study of 19,947 individuals. The Tromsø study 

      Bugge, Erlend; Wynn, Rolf; Mollnes, Tom Eirik; Reitan, Solveig Merete Klæbo; Lapid, Maria I.; Grønli, Ole Kristian (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-17)
      In recent years, a connection between depression and inflammation has been established, with a range of immunological changes, both cellular and humoral, presenting during depressive states (Beydoun et al., 2016; Haapakoski et al., 2015; Wium-Andersen et al., 2013). Furthermore, there seems to be a dose-response relationship between depression and inflammation, in the sense that the more severe the ...
    • Changes in cytokines during treatment of elderly, hospitalized psychiatric patients - a naturalistic study 

      Bugge, Erlend; Wynn, Rolf; Mollnes, Tom Eirik; Reitan, Solveig Merete Klæbo; Lapid, Maria; Grønli, Ole Kristian (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-26)
      Immunological abnormalities have been demonstrated in several psychiatric disorders. Predominantly, studies have focused on younger adults, and research on elderly psychiatric in-patients is scant. In this naturalistic study, we investigated changes in cytokine levels during the treatment of diagnostically unselected elderly psychiatric in-patients, and whether these changes could be related to ...
    • Cytokine profiles and diagnoses in elderly, hospitalised psychiatric patients 

      Bugge, Erlend; Wynn, Rolf; Mollnes, Tom Eirik; Reitan, Solveig Merete Klæbo; Grønli, Ole Kristian (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-27)
      <p><i>Background:</i> There is a paucity of studies on inflammatory markers in elderly psychiatric patients. Hence, our study was undertaken to investigate cytokines as biomarkers in diagnostically unselected elderly patients admitted to a psychiatric hospital. <p><i>Methods:</i> Demographic data, clinical data and blood samples, including 27 cytokines, were collected from 98 patients above 60 ...
    • Probable clozapine-induced parenchymal lung disease and perimyocarditis: A case report 

      Bugge, Erlend; Nissen, Trygve; Wynn, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-08)
      <p><i>Background:</i> Clozapine is the archetypical atypical antipsychotic, its primary indication being treatment resistant schizophrenia. Severe side effects caused by clozapine, including leukopenia, agranulocytosis, and myocarditis, are well known. A rarely described side effect is concurrent perimyocarditis and parenchymal lung disease. <p><i>Case presentation:</i> A previously physically ...
    • Some systemic markers of inflammation in older adults with psychiatric disorders 

      Bugge, Erlend (Doctoral thesis; Doktorgradsavhandling, 2022-12-02)
      Research has demonstrated that inflammation is a central part of several psychiatric disorders, of which depression in the most researched condition. Most studies have, however, been conducted on younger adults, and studies on elderly are scarce. This thesis explores the possible association between systemic markers of inflammation and characteristics of older psychiatric patients. In study I, ...